Highly oxidized sesquiterpenoids from Parasenecio rubescens and assessment of their cytotoxicity
10.1016/S1875-5364(24)60607-2
- Author:
An JIN
1
,
2
;
Fangfang DUAN
;
Hanli RUAN
Author Information
1. Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation,School of Pharmacy,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China
2. School of Pharmaceutical Sciences,Hunan University of Medicine,Huaihua 418000,China
- Keywords:
Parasenecio rubescens;
Asteraceae;
Bisabolane-type sesquiterpenoids;
Oplopane-type sesquiterpenoid;
Cytotoxic activity
- From:
Chinese Journal of Natural Medicines (English Ed.)
2024;22(11):1020-1029
- CountryChina
- Language:Chinese
-
Abstract:
A phytochemical investigation of the whole plant of Parasenecio rubescens(S.Moore)Y.L.Chen yielded 14 previ-ously undescribed,highly oxidized bisabolane-type sesquiterpenoids,named pararunines L-Y,along with one known oplopane-type sesquiterpenoid.The structural elucidation of these compounds was accomplished through comprehensive spectroscopic analysis,in-cluding nuclear magnetic resonance(NMR)and high-resolution electrospray ionization mass spectrometry(HR-ESI-MS)techniques.Motivated by traditional uses and previous studies on this genus,all isolated compounds were subjected to in vitro cytotoxicity assays against four human cancer cell lines(MCF-7,Hela,HCT116,and HT-29).Considering that the reported chemical constituents of nu-merous other species within this genus primarily consist of eremophilane-type sesquiterpenoids,our findings not only expand the struc-tural diversity of bisabolane-type sesquiterpenoids but also contribute valuable scientific evidence to the chemotaxonomy of this genus.
