Clinical Factors Associated With Dose Escalation of Solifenacin for the Treatment of Overactive Bladder in Real Life Practice.
- Author:
Ji Youn CHUN
1
;
Miho SONG
;
Ji Yeon HAN
;
Selee NA
;
Bumsik HONG
;
Myung Soo CHOO
Author Information
1. Department of Urology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. mschoo@amc.seoul.kr
- Publication Type:Original Article
- Keywords:
Overactive urinary bladder;
Muscarinic antagonists;
Solifenacin
- MeSH:
Elevators and Escalators;
Humans;
Muscarinic Antagonists;
Solifenacin Succinate;
Urinary Bladder, Overactive*;
Urinary Incontinence
- From:International Neurourology Journal
2014;18(1):23-30
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: To determine the baseline clinical characteristics associated with dose escalation of solifenacin in patients with overactive bladder (OAB). METHODS: We analyzed the data of patients with OAB (micturition frequency > or =8/day and urgency > or =1/day) who were treated with solifenacin and followed up for 24 weeks. According to our department protocol, all the patients kept voiding diaries, and OAB symptom scores (OABSS) were monitored at baseline and after 4, 12, and 24 weeks of solifenacin treatment. RESULTS: In total, 68 patients (mean age, 60.8+/-10.0 years) were recruited. The dose escalation rate by the end of the study was 41.2%, from 23.5% at 4 weeks and 17.6% at 12 weeks. At baseline, the dose escalator group had significantly more OAB wet patients (53.6% vs. 20.0%) and higher total OABSS (10.2+/-2.4 vs. 7.9+/-3.5, P=0.032) than the nonescalator group. OAB wet (odds ratio [OR], 4.615; 95% confidence interval [CI], 1.578-13.499; P<0.05) and total OABSS (OR, 1.398; 95% CI, 1.046-1.869; P<0.05) were found to be independently associated with dose escalation. CONCLUSIONS: Patients who have urgency urinary incontinence and high total OABSS have a tendency for dose escalation of solifenacin.
