New nor-ent-halimane and nor-clerodane diterpenes from Callicarpa integerrima with anti-MRSA activity
10.1016/S1875-5364(24)60575-3
- Author:
Mengru WANG
1
;
Qi WANG
;
Yanzi MA
;
Aurang Muhammad ZEB
;
Xiaoli LI
;
Feng SHEN
;
Weilie XIAO
Author Information
1. Key Laboratory of Medicinal Chemistry for Natural Resource,Ministry of Education,Yunnan Characteristic Plant Extraction Laboratory,Yunnan Key Laboratory of Research and Development for Natural Products,State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan,School of Pharmacy and School of Chemical Science and Technology,Yunnan Uni-versity,Kunming 650500,China
- Keywords:
Callicarpa integerrima;
Halimane diterpenes;
Clerodane diterpenes;
Structure elucidation;
anti-MRSA
- From:
Chinese Journal of Natural Medicines (English Ed.)
2024;22(11):1003-1010
- CountryChina
- Language:Chinese
-
Abstract:
Two new nor-ent-halimane diterpenes and three previously unreported nor-clerodane diterpenes,designated callicain-tides A-E(1-5),were isolated from Callicarpa integerrima.Compounds 1 and 2 feature a distinctive 5/6-membered ring system,while compounds 3-5 are characterized by progressively truncated carbon skeletons,containing 18,17,and 16 carbons,respectively.In addition,four known compounds 6-9 were also identified.Their structures were elucidated using advanced spectroscopic tech-niques,including nuclear magnetic resonance(NMR),high-resolution electrospray ionization mass spectrometry(HR-ESI-MS),ultra-violet(UV),infrared radiation(IR),optical rotatory dispersion(ORD),DP4+analysis and electronic circular dichroism(ECD),sup-ported by quantum chemical calculations.Compounds 1-9 were evaluated for their anti-MRSA activity.Among them,compound 6 demonstrated significant anti-MRSA activity,with a minimum inhibitory concentration(MIC)of 16 μg·mL-1.
