Research progress on the mechanism of the effect of GLP-1 receptor agonists on cognitive function in patients with type 2 diabetes mellitus

VernacularTitle:胰高血糖素样肽1受体激动剂对2型糖尿病患者认知功能影响机制的研究进展
Author: Xiaoya ZHANG ¹ ; Lu YUAN ; Jindan WU
Author Information

1. 210006 南京医科大学附属南京医院内分泌科
Keywords: Diabetes mellitus,type 2; Glucagon-like peptide-1 receptor agonists; Cognitive function
From: Chinese Journal of Diabetes 2024;32(11):871-875
CountryChina
Language:Chinese
Abstract: Type 2 diabetes mellitus(T2DM)can lead to changes in brain structure and function,increasing the risk of cognitive impairment and dementia.The mechanism may be related to insulin resistance(IR),impaired insulin signal transduction,and cerebral vascular disease.Glucagon-like peptide 1 receptor agonists(GLP-1RAs)are a class of new drugs in treating T2DM,which can lower blood glucose,delay gastric emptying,and increase satiety,thereby reduce body weight.In recent years,more and more researchers have conducted animal experiments and clinical trials to explore the effects of GLP-1RAs,especially Liraglutide and Exenatide,on cognitive function in patients with T2DM and related mechanisms.This review summarizes the effects of GLP-1RAs on cognitive function in patients with T2DM and their possible mechanisms.