Immune checkpoint inhibitor associated diabetes mellitus:four cases report
10.3969/j.issn.1006-6187.2024.11.009
- VernacularTitle:免疫检查点抑制剂相关糖尿病四例报道
- Author:
Wenzhan CHEN
1
;
Leshan CHEN
;
Haiying HU
;
Youming CHEN
;
Huiting TAN
;
Jingsong CHEN
;
Xuejuan XU
Author Information
1. 528000 佛山市第一人民医院内分泌科
- Keywords:
Immune checkpoint inhibitor;
Diabetes mellitus;
Programmed cell deathprotein 1 inhibitor;
Programmed cell deathligand 1 inhibitor
- From:
Chinese Journal of Diabetes
2024;32(11):856-860
- CountryChina
- Language:Chinese
-
Abstract:
Immune checkpoint inhibitor(ICI)associated diabetes mellitus(DM)a rare specific type of diabetes,usually developed after the treatment of programmed cell death protein 1(PD-1)inhibitor or programmed cell death ligand 1(PD-L1)inhibitor.We reported 4 cases of DM after ICI use.These patients had a subacute onset,6 to 17 months after the first use of the drug,with diabetic autoantibodies negative.Pancreas atrophy was observed in one of them.All of the patients received treatment of insulin.
