Correlation of serum Metrnl levels with glycolipid metabolism and inflammatory status in patients with type 2 diabetes mellitus combined with abdominal obesity
10.3969/j.issn.1006-6187.2024.10.001
- VernacularTitle:2型糖尿病腹型肥胖患者血清镍纹样蛋白水平与糖脂代谢和炎症状态相关性的研究
- Author:
Ziying WEN
1
;
Jing LIU
;
Jing YU
;
Jumei QIU
;
Fan YANG
;
Ruixia YANG
;
Qi ZHANG
Author Information
1. 730000 兰州,甘肃中医药大学第一临床医学院
- Keywords:
Diabetes mellitus,type 2;
Abdominal obesity;
Nickel-like protein;
Glucose and lipid metabolism;
Inflammatory state
- From:
Chinese Journal of Diabetes
2024;32(10):721-725
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between serum nickel-like protein(Metrnl)level and glycolipid metabolism and inflammatory state in patients with T2DM complicated with abdominal obesity.Methods One hundred and twenty-four T2DM patients and 140 non-diabetic controls who were hospitalized in Gansu Provincial People's Hospital from May to September 2022 were selected and divided into T2DM combined abdominal obesity group(T2DM+AO,n=81),T2DM group(n=43),abdominal obesity group(AO,n=69)and normal control group(NC,n=71)according to whether they suffered from T2DM and abdominal obesity.ELISA method was used to determine the levels of serum Metrnl,IL-4 and IL-13.The correlation between serum Metrnl and the indicators of glucose and lipid metabolism,WC,BMI,VFA,FPG,HbA1c,TC,TG,LDL-C,HDL-C and the indicators of inflammatory state,IL-4 and IL-13 were analyzed.Results Compared with NC group,serum Metrnl levels in T2DM group,AO and T2DM+AO group were decreased(P＜0.05).Serum Metrnl was negatively correlated with WC,BMI,VFA,FPG,HbA1c,TG,IL-4,IL-13(P＜0.01),and positively correlated with HDL-C(P＜0.05).Age,WC,BMI and IL-4 were the influencing factors of Metrnl.WC,VFA,FPG and Metrnl were the influencing factors of T2DM combined with abdominal obesity.The ROC curve showed that serum Metrnl had a sensitivity of 82.5%and a specificity of 93.8%for the diagnosis of T2DM with abdominal obesity.Conclusions Serum Metrnl in T2DM patients with abdominal obesity is significantly reduced,and is closely related to glucose and lipid metabolism and inflammatory status.Serum Metrnl may be a novel biomarker factor for T2DM complicated with abdominal obesity.
