Insulin pump intensive treatment and insulin aspart+insulin glargine 3+1 intensive treatment
10.3969/j.issn.1006-6187.2024.09.009
- VernacularTitle:胰岛素泵强化治疗和门冬胰岛素加甘精胰岛素3+1强化治疗的效果观察
- Author:
Jingfen XIA
1
;
Jiping LU
;
Lei CHEN
Author Information
1. 214400 江阴市第三人民医院内科
- Keywords:
Insulin pump;
Insulin glargine;
Insulin aspart;
Diabetes melliitus,type 2;
Intensive treatment
- From:
Chinese Journal of Diabetes
2024;32(9):680-683
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the effects of intensive treatment with insulin pump and insulin aspart+insulin glargine 3+1.Methods Fifty patients with type 2 diabetes mellitus(T2DM)in our hospital were randomly divided into insulin aspart+insulin glargine(Asp+Gla)group and insulin pump(IP)group,with 25 cases in each group.Compare the general data,biochemical indicators,serum malondialdehyde(MDA),catalase(CAT),superoxide dismutase(SOD)and adverse reactions between the two groups,and calculate the insulin resistance index(HOMA-IR)and islet β function index(HOMA-β).Results HOMA-β,HDL-C,SOD and CAT in the two groups were higher than those before treatment(P<0.05),while FPG,2 hPG,GA,HOMA-IR,TG,TC,LDL-C and MDA were lower than those before treatment(P<0.05).Compared with Asp+Gla group after treatment,HDL-C,SOD and CAT in IP group increased(P<0.05),while FPG,2 hPG,GA,HOMA-β,HOMA-IR,TG,TC,LDL-C and MDA decreased(P<0.05).Conclusions Intensive treatment with insulin pump can more effectively regulate the level of glucose and lipid metabolism,improve insulin β function and reduce oxidative stress,which is safe and effective.
