Correlation between serum 25-hydroxyvitamin D level and diabetic kidney disease in patients with type 2 diabetes mellitus
10.3969/j.issn.1006-6187.2024.09.006
- VernacularTitle:2型糖尿病患者血清25羟维生素D水平与糖尿病肾脏疾病相关性的研究
- Author:
Jiao YAN
1
;
Qinjian XU
;
Junwei ZHANG
;
Qifang MENG
Author Information
1. 314100 嘉善县第二人民医院内分泌科
- Keywords:
Diabetes mellitus,type 2;
25-hydroxyvitamin D;
Diabetic kidney disease
- From:
Chinese Journal of Diabetes
2024;32(9):667-670
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between serum 25-hydroxyvitamin D[25(OH)D]level and diabetic kidney disease(DKD)in patients with type 2 diabetes mellitus(T2DM).Methods A total of 174 T2DM patients admitted to Jiashan County Second People's Hospital from May 2019 to May 2021 were selected and divided into normal albuminuria(NUAlb)group(<30 mg/g,n=71),microalbuminuria(MUAlb)group(30～300 mg/g,n=85)and large albuminuria(LUAlb)group(≥300 mg/g,n=18)according to the urine albumin-creatinine ratio(UACR)level.The levels of 25(OH)D in each group and its relationship with UACR were analyzed.Results The age,DM duration,use of ACEI or ARBs,SBP,DBP,FPG,SUA,proportion of 25(OH)D<30 nmol/L and UACR in NUAlb,MUAlb,LUAlb graup increased in turn(P<0.05).Spearman correlation analysis showed that UACR in T2DM patients was positively correlated with gender,age,DM duration,BMI,SBP,DBP,FPG,HbA1c,TG,and SUA(P<0.05),and negatively correlated with HDL-C and 25(OH)D(P<0.05).Logistic regression analysis showed that gender,SBP,HbA1c,SUA,and 25(OH)D were influencing factors for albuminuria in T2DM patients.Conclusions T2DM patients have 25(OH)D shortage,especially in DKD patients.25(OH)D deficiency is closely related to proteinuria in T2DM patients.
