Correlation between monocyte/high-density lipoprotein cholesterol ratio and renal tubular injury and decreased renal function in patients with type 2 diabetes mellitus
10.3969/j.issn.1006-6187.2024.09.005
- VernacularTitle:血单核细胞/高密度脂蛋白胆固醇比值与2型糖尿病患者肾小管损伤和肾功能下降相关性的研究
- Author:
Yue WANG
1
;
Juan SUN
;
Miaomiao HE
Author Information
1. 221004 徐州医科大学第一临床医学院
- Keywords:
Diabetes mellitus,type 2;
Renal tubule injury;
Decreased kidney function;
Monocyte/high-density lipoprotein cholesterol ratio
- From:
Chinese Journal of Diabetes
2024;32(9):662-666
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between monocyte/high-density lipoprotein cholesterol ratio(MHR)and renal tubule injury and decreased renal function in patients with type 2 diabetes mellitus(T2DM).Methods A total of 326 patients with T2DM who were hospitalized in The Department of Endocrinology,Affiliated Hospital of Xuzhou Medical University were enrolled in this study from September 2021 to March 2023.All the participants were divided into three groups according to urinary alpha1 microglobulin to creatinine ratio(MCR)and estimated glomerular filtration rate(eGFR):normal tubules with normal renal function(RTN+RFN,n=177),impaired tubules with normal renal function(RTI+RFN,n=100),and impaired tubules with decreased renal function(RTI+RFD,n=49).Results MHR was higher in RTI+RFD group than in RTN+RFN group and RTI+RFN group.MHR was higher in RTI+RFN group than in RTN+RFN group(P<0.05).Spearman correlation analysis showed that MHR was positively correlated with MCR and UACR(P<0.05),and negatively correlated with eGFR(P<0.05).Logistic regression analysiss showed that MHR and UACR were independent influencing factors for renal tubular injury in T2DM patients,and MHR,UACR and MCR were influential factors for renal function decline in T2DM patients(P<0.05).ROC curve analysis showed that the area under the curve of MHR was 0.794 and 0.779 in predicting tubular injury and renal function decline respectively in T2DM.Conclusions MHR is an influential factor for renal tubular injury and renal function decline.MHR is valuable in the diagnosis of rendl tubular injury and decreased renal function in T2DM patients.
