Correlation analysis of fragmented QRS on electrocardiogram and microalbuminuria and serum uric acid in patients with type 2 diabetes mellitus
10.3969/j.issn.1006-6187.2024.09.003
- VernacularTitle:2型糖尿病患者心电图碎裂QRS波与血尿酸、尿微量蛋白相关性的研究
- Author:
Lili WANG
1
;
Lifang BAO
;
Linjun ZHENG
;
Jiayu HU
;
Huaying HUANG
;
Jun JIANG
Author Information
1. 310009 杭州,浙江大学医学院附属第二医院心血管内科
- Keywords:
Electrocardiogram;
Fragmented QRS;
Microalbuminuria;
Serum uric acid;
Diabetes mellitus,type 2
- From:
Chinese Journal of Diabetes
2024;32(9):652-656
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the relationship between fragmented QRS(fQRS)and microalbuminuria(MAU)and serum uric acid(SUA)in patients with type 2 diabetes mellitus(T2DM).Methods From October 2022 to June 2023,245 T2DM patients diagnosed by The Department of Endocrinology,Jinhua Hospital Affiliated to Zhejiang University School of Medicine were selected and divided into fQRS group(fQRS,n=111)and T2DM group(n=134)according to ECG results.The general data,biochemical indexes,left ventricular end-diastolic diameter(LVEDd),left ventricular end-systolic diameter(LVESd),interventricular septum(IVS),left ventricular posterior wall(LVPW),left ventricular ejection fraction(LVEF),left atrial diameter(LAd),peak value ratio of mitral orifice blood flow velocity in early and late diastole(E/A)and mitral orifice blood flow velocity in early diastole were compared between the two groups.Pearson correlation analysis was used to analyze the correlation between fQRS wave and other indexes in T2DM patients,and Logistic regression analysis was used to analyze the influencing factors of fQRS.Results The prevalence rates of UACR,SUA,HbA1c and MAU in fQRS group were higher than in T2DM group(P＜0.05 or P＜0.01).LVEDd,LAd,E,E/e'and E/A>1.5 in QRS group were higher than in T2DM group(P＜0.05 or P＜0.01).Pearson correlation analysis showed that fQRS wave was positively correlated with smoking history,BMI,HbA1c,UACR,MAU,SUA,LVEDd,LAd,E/A and E/e'(P＜0.05).Logistic regression analysis showed that MAU was the influencing factor of fQRS wave in T2DM patients.Conclusions The fQRS in ECG in patients with T2DM is associated with MAU and SUA and may be an important evidence of myocardial fibrosis associated with subclinical cardiac diastolic dysfunction.
