Research progress on the role of epigenetic effects in diabetic peripheral neuropathy

VernacularTitle:糖尿病周围神经病变的表观遗传作用研究进展
Author: Min LI ¹ ; Simiao GONG ; Yuting GUO ; Hang ZHANG ; Yan YANG
Author Information

1. 610075 成都中医药大学养生康复学院
Keywords: Diabetic peripheral neuropathy; Epigenetic; DNA methylation; Histone modification
From: Chinese Journal of Diabetes 2024;32(8):630-633
CountryChina
Language:Chinese
Abstract: The pathogenesis of diabetic peripheral neuropathy(DPN)is driven by environmental factors,which can induce epigenetic changes and make it a bridge between environment and gene expression.Hyperglycemia causes changes in DNA methylation,abnormal regulation of enzyme activity involved in his tone modification,and is associated with chromatin structural modification,leading to alterations in DPN gene expression.This article reviews the research progress of epigenetic effects on DPN.