Lilaglutide improved hepatocyte senescence and liver fibrosis in diabetic mice
10.3969/j.issn.1006-6187.2024.08.012
- VernacularTitle:利拉鲁肽改善糖尿病小鼠肝脏衰老和纤维化的研究
- Author:
Weiyu CHEN
1
;
Zhiyan PU
;
Yanxia YANG
Author Information
1. 730000 兰州,甘肃省第二人民医院内分泌科
- Keywords:
Liraglutide;
Liver inflammation;
Fibrosis;
Diabetes mellitus
- From:
Chinese Journal of Diabetes
2024;32(8):623-629
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of Liraglutide on alleviating the liver injury inmice with DM,and to evaluate the effects of Liraglutide on liver fibrosis,liver aging and liver oxidative stress.Methods Thirty C57BL/6J mice were randomly divided into normal control group(Con),model group(Mod)and Liraglutide group(Lir),with 10 mice in each group.The expressions of p21,p16,p53,inflammatory factors TNF-α and IL-1β were detected by Western blot.The effects of Liraglutide on liver fibrosis were analyzed by Masson and Sirius scarlet staining.The oxidative stress Lndexes of reactive oxygen species(ROS),superoxide dismutase(SOD)and malondialdehyde(MDA)were compared among the groups.Results The expressions of TNF-α,IL-6,IL-1β,NLRP3,p16,p21,p53,p15,TNF-α,IL-6,IL-1β,NLRP3 and α-SMA were higher in Mod group than in Con and Lir groups(P<0.05).ROS and MDA were higher,while SOD and GSH-PX were lower in Mod group than in Con and Lir group(P<0.05).The positive areas of Sirius scarlet and Masson staining were higher in Mod group than in Con and Lir groups(P<0.05).Conclusions Liraglutide can alleviate liver aging,inflammation and fibrosis,and has protective effect on liver injury caused by DM.
