Correlation between dynamic blood glucose monitoring parameters and nerve conduction velocity in patients with diabetic periheral neuropathy
10.3969/j.issn.1006-6187.2024.08.008
- VernacularTitle:糖尿病周围神经病变患者动态血糖监测参数与神经传导速度相关性的研究
- Author:
Bo JI
1
;
Yanqing MA
;
Fengguo LI
Author Information
1. 467000 平顶山,平煤神马医疗集团总医院内分泌一区
- Keywords:
Diabetic peripheral neuropathy;
Continuous glucose monitoring;
Nerve conduction velocity;
Correlation
- From:
Chinese Journal of Diabetes
2024;32(8):601-607
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the correlation between continues glucose monitoring(CGM)parameters and nerve conduction velocity(NCV)in patients with diabetic peripheral neuropathy(DPN).Methods A total of 180 T2DM patients who visited our Endocrinology Department were enrolled in this study from June 2020 to June 2022 and divided into simple type 2 diabetes mellitus(T2DM)group(n=30)and a T2DM combined with DPN group(DPN,n=150)based on whether they had DPN.The DPN group was further divided into mild DPN subgroup(VPT 16～24 V,n=51),moderate DPN subgroup(VPT 25～39 V,n=67),and severe DPN subgroup(VPT≥40 V,n=32)according to the VPT.Results Compared with T2DM group,DM duration,SUA,TBIL,AST,TC,TG,LDL-C and GSP were increased in DPN group(P<0.05 or P<0.01).MAGE,LAGE,MBG,SDBG and FBG-CV in mild,moderate and severe subgroups of DPN increased in turn(P<0.01),while TIR,MNCV and SNCV decreased in turn(P<0.01).Hierarchical regression model analysis showed that MAGE,LAGE,MBG,FBG-CV were the influencing factors for MNCV and SNCV.Logistic regression analysis showed that MAGE,LAGE,MBG,FBG-CV,MNCV and SNCV were all influencing factors for DPN severity.Interaction analysis showed that MNCV,SNCV,MAGE,LAGE,MBG and FBG-CV all had additive and multiplying interactions on the severity of DPN.Conclusions MAGE,LAGE,MBG,FBG-CV,MNCV,and SNCV are factors that affect the severity of DPN,with additive and multiplicative interactions present.
