Research progress IL-1β in the mechanism of action and clinical treatment of diabetic retinopathy
10.3969/j.issn.1006-6187.2024.07.015
- VernacularTitle:糖尿病视网膜病变中IL-1β的作用及治疗机制的研究进展
- Author:
Fang CHEN
1
;
Haiyan WEI
;
Pengxiang XU
;
Shuqin ZENG
;
Weiming LYU
;
Rong XU
Author Information
1. 341000 赣州,赣南医科大学第一附属医院内分泌科
- Keywords:
IL-1β;
Diabetic retinopathy;
Mechanism of action
- From:
Chinese Journal of Diabetes
2024;32(7):557-560
- CountryChina
- Language:Chinese
-
Abstract:
Diabetic retinopathy(DR)is the main cause of blindness and visual impairment.In hyperglycemia,oxidative stress,or hypoxia,IL-1β upregulation mediates retinal inflammation.Sustained low-grade inflammation can cause retinal vascular damage and neurodegeneration,stimulate oxidative damage,disrupt the blood retinal barrier,and induce retinal neovascularization.This article reviews the research progress of IL-1β in the mechanism and clinical treatment of DR.
