The correlation between sleep disorder and bone mineral density and fracture risk in patients with type 2 diabetes mellitus
10.3969/j.issn.1006-6187.2024.07.008
- VernacularTitle:2型糖尿病患者睡眠障碍与骨密度及骨折风险相关性的研究
- Author:
Jiali QIN
1
;
Minting HUANG
;
Xingyao XIAO
;
Huanjun WANG
;
Lin LI
;
Yinzhen PI
Author Information
1. 421001 衡阳,南华大学衡阳医学院长沙市第一医院研究生协作培养基地
- Keywords:
Diabetes mellitus,type 2;
Sleep disorder;
Bone mineral density;
Fracture risk
- From:
Chinese Journal of Diabetes
2024;32(7):519-523
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the correlation between sleep disorder and bone mineral density(BMD)and fracture risk in middle-aged and elderly patients with type 2 diabetes mellitus(T2DM).Methods 150 T2DM patients over 50 years old who were hospitalized in the Endocrine Metabolism Department of Changsha First Hospital from September 2022 to April 2023 were selected.According to the Pittsburgh Sleep Quality Index(PSQI),they were divided into a non-sleep disorder group(66 cases)and a sleep disorder group(84 cases).The general data and biochemical indicators of the two groups were compared.The relationship between sleep disorder and BMD,fracture risk was analyzed.Results Compared with the non-sleep disorder group,HbA1c,FPG,female proportion,the proportion of hypnotics and risk scores of vertebral fracture in the sleep disorder group were higher,and BMI,BMD of femoral neck and hip were lower(P<0.05).Pearson correlation analysis showed a negative correlation between PSQI score and BMD of femoral neck and hip(P<0.05).Pearson or Spearman correlation analysis showed that the risk scores of vertebral fracture was positively correlated with age,duration of DM,use of hypnotics and sleep disorder(P<0.05 or P<0.01),and negatively correlated with BMD of femoral neck and hip(P<0.01).Binary logistic regression analysis showed that FPG,use of hypnotics and hip BMD were influencing factors of sleep disorders,while sleep disorders and PSQI scores were influencing factors of osteoporosis.Conclusions For middle-aged and elderly T2DM patients,improving sleep may help reduce the occurrence of osteoporosis and reduce the risk of fractures.
