Effects of oxidative stress on TIR in patients with type 2 diabetes mellitus and sleep apnea-hypopnea syndrome
10.3969/j.issn.1006-6187.2024.07.007
- VernacularTitle:2型糖尿病合并睡眠呼吸暂停低通气综合征患者氧化应激对血糖波动影响的研究
- Author:
Yonghong ZHANG
1
;
Linhui CHEN
;
Qiang LIU
;
Yi WANG
;
Lijuan YUAN
;
Jianfang GONG
;
Fuguo ZHANG
;
Yanhong FENG
;
Junli SHI
;
Hong LUO
;
Juming LU
;
Jie LIU
Author Information
1. 030000 太原糖尿病专科医院
- Keywords:
Diabetes mellitus,type 2;
Sleep apnea-hypopnea syndrome;
Oxidative stress;
Insulin resistance;
Time in range
- From:
Chinese Journal of Diabetes
2024;32(7):515-518
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the characteristics of time in range(TIR)and its relationship with oxidative stress(OS)and insulin resistance status(HOMA-IR)in patients with type 2 diabetes mellitus(T2DM)and sleep apnea-hypopnea syndrome(OSAHS).Methods According to apnea-hypopnea index(AHI),165 T2DM in patients were divided into simple T2DM group(AHI<5 times/h,n=43),T2DM combine OSAHS mild group(OSAHS-G,5≤AHI<15 times/h,n=51),T2DM combined OSAHS moderate group(OSAHS-M,15≤AHI≤30 times/h,n=40)and T2DM combine OSAHS severe group(OSAHS-S,AHI>30 times/h,n=31).TIR was calculated by dynamic blood glucose monitoring.Superoxide dismutase(SOD),glutathione peroxidase(GSH-Px)and other indexes were detected and analyzed.Results Compared with simple T2DM group,the levels of HOMA-IR,8-iso-PGF2a and Ox-LDL were higher in T2DM combined OSAHS-G,OSAHS-M or OSAHS-S group,while the levels of TIR,SOD and GSH-Px were lower(P<0.05).Pearson correlation analysis showed that TIR was positively correlated with the levels of SOD and GSH-Px(P<0.05 or P<0.01),and negatively correlated with the levels of 8-iso-PGF2a,Ox-LDL,HbA1c,HOMA-IR and the severity of OSAHS(P<0.01).Logistic regression analysis showed that TIR,SOD and GSH-Px were protective factors for severe OSAHS in T2DM patients,while 8-iso-PGE2a and Ox-LDL were the risk factors for severe OSAHS.Conclusions The glucose level fluctuates greatly in patients with T2DM and OSAHS.Insulin resistance and oxidative stress are factors that affect the normalization of TIR.
