Relationship between serum miR-195 levels in patients with type 2 diabetes mellitus and metabolic associated fatty liver disease
10.3969/j.issn.1006-6187.2024.07.004
- VernacularTitle:血清miR-195与2型糖尿病合并代谢相关脂肪性肝病相关性的研究
- Author:
Qian CHEN
1
;
Jinxing QUAN
;
Yaya LYU
;
Yangyang ZHANG
;
Jing LIU
;
Juxiang LIU
Author Information
1. 750004 银川,宁夏医科大学第一临床医学院
- Keywords:
miR-195;
Diabetes mellitus,type 2;
Metabolic associated fatty liver disease;
Insulin resistance;
Inflammatory response
- From:
Chinese Journal of Diabetes
2024;32(7):501-504
- CountryChina
- Language:Chinese
-
Abstract:
Objective To exploring the correlation between serum miR-195 and metabolic associated fatty liver disease(MAFLD)in type 2 diabetes mellitus(T2DM)patients.Methods A total of 79 patients with T2DM who were treated in the Endocrinology Department of Gansu Provincial People's Hospital were enrolled in this study from October 2022 to August 2023.They were divided into simple T2DM(n=37)and MAFLD group(MAFLD,n=42)according to whether they were complicated with MAFLD.Meanwhile,34 healthy individuals who underwent physical examinations were selected as the normal control(NC)group.Results Compared with the NC group,FPG,HbA1c and HOMA-IR increased,while HDL-C decreased in T2DM and MAFLD group(P<0.05).The TG and hs-CRP levels were higher in MAFLD group than in NC and T2DM group(P<0.05).The serum miR-195 expression decreased sequentially(P<0.05),while FAS increased sequentially in NC,T2DM,and MAFLD group(P<0.05).Spearman correlation analysis showed that miR-195 was negatively correlated with FPG,HOMA-IR,hs-CRP,and FAS(P<0.05).Multiple linear regression analysis showed that HOMA-IR and FAS were the influencing factors for serum miR-195.Conclusions Down-regulation of serum miR-195 expression in patients with T2DM combined with MAFLD may be by glucose and lipid metabolism,IR and inflammatory response.
