Association between variation of WFS1 gene and early-onset type 2 diabetes mellitus in Chinese population
10.3969/j.issn.1006-6187.2024.07.001
- VernacularTitle:中国人群中WFS1基因变异与早发2型糖尿病相关性的研究
- Author:
Chanwei LIU
1
;
Xiaoxu GE
;
Ming LI
;
Tiantian LI
;
Langen ZHUANG
;
Rong ZHANG
;
Juan ZHANG
;
Yating CHEN
;
Fusong JIANG
;
Limei LIU
Author Information
1. 200233 上海交通大学医学院附属第六人民医院内分泌代谢科
- Keywords:
WFS1 gene;
rs734312 variation;
Diabetes mellitus,type 2;
Early-onset
- From:
Chinese Journal of Diabetes
2024;32(7):481-487
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the association between R611H(G/A,rs734312)variation of WFS1 gene and early-onset type 2 diabetes mellitus(T2DM).Methods A total of 181 Chinese patients with early-onset T2DM(T2DM group)and 196 non-diabetic controls(NC group)were enrolled in this study.The rs734312 variation was detected by PCR-direct sequencing.Genotypic and allelic frequencies of rs734312 and clinical variables were compared and analyzed between the two groups.Results Compared with the NC group,the frequencies of AA genotype and A allele in R611H(G→A)variation were significantly elevated in the early-onset T2DM group,AA vs GA+GG(OR 1.720,95%CI 1.100～2.680,P<0.05).A vs G(OR 1.500,95%CI 1.020～2.220,P<0.05).The remarkable differences of frequencies of genotype and allele in rs734312(G/A)were observed between Asians(China,Japan and Korea)and Caucasians(Denmark,Britain,Spain,France and Russia,P<0.01 for each).Compared with AA genotype,fasting and 2 hours postprandial insulin(FIns and 2 hIns)as well as HOMA-β were significantly rise in GG+GA genotype carriers of early-onset T2DM group(P<0.05).Conclusions The a allele of rs734312 in WFS1 may be a risk factor for early-onset T2DM in Chinese population,and the variation might be a potential genetic marker for predicting the islet β-cell dysfunction in early-onset T2DM in Chinese population.
