AGEs-RAGE axis mediate p38MAPK signal pathway to regulate the mechanism of osteoblasts in diabetic osteoporosis
10.3969/j.issn.1006-6187.2024.06.015
- VernacularTitle:晚期糖基化终产物-糖基化终产物受体轴介导p38丝裂原活化蛋白激酶信号通路调控成骨细胞在糖尿病性骨质疏松中作用机制的研究进展
- Author:
Taomei MA
1
;
Shijie HAN
;
Lan MA
;
Xiaoqing ZHOU
;
Xiaohui WANG
Author Information
1. 730030 兰州,甘肃中医药大学
- Keywords:
AGEs-RAGE;
p38MAPK;
Signaling pathway;
Osteoblasts;
Diabetic osteoporosis
- From:
Chinese Journal of Diabetes
2024;32(6):474-477
- CountryChina
- Language:Chinese
-
Abstract:
Diabetic osteoporosis(DOP)is a serious complication of diabetes mellitus(DM),with bone loss and microstructure destruction.The onset of DOP is insidious,and early symptoms are not obvious.As the condition progresses,the disability and mortality rates increase in DM patients.The advanced glycation end products receptor(AGEs-RAGE)axis can mediate different signaling pathways involved in regulating osteoblasts.This article reviews the mechanism of AGEs-RAGE axis mediated p38 mitogen activated protein kinase signaling pathway in regulation of osteoblasts in DOP.
