Correlation research on metabolic associated fatty liver disease with bone mineral density in patients with type 2 diabetes mellitus
10.3969/j.issn.1006-6187.2024.06.008
- VernacularTitle:2型糖尿病患者骨密度与代谢相关脂肪性肝病相关性的研究
- Author:
Siping HE
1
;
Yuzhen LIANG
Author Information
1. 530000 南宁,广西医科大学第二附属医院内分泌科
- Keywords:
Diabetes mellitus,type 2;
Metabolic associated fatty liver disease;
Bone mineral density
- From:
Chinese Journal of Diabetes
2024;32(6):437-442
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association between bone mineral density(BMD)and metabolic associated fatty liver disease(MAFLD)in patients with type 2 diabetes mellitus(T2DM).Methods A total of 300 patients with T2DM were enrolled and divided into T2DM with MAFLD group(n=162)and T2DM without MAFLD group(n=138)according to controlled attenuation parameters(CAP).The bone mineral density(BMD)of the patients was measured by dual energy X-ray absorptiometer.Results Compared with T2DM group,BMI,abdominal circumference(AC),FIns,FC-P,TG,HOMA-IR,ALB,liver stiffness measurement(LSM),CAP and BMD in T2DM+MAFLD group increased(P<0.05),while HDL-C and alkaline phosphatase(ALP)decreased(P<0.01).Spearman correlation analysis showed that the overall BMD of the male lumbar spine was positively correlated with smoking,AC,BMI,CAP,FIns,FC-P,HOMA-IR(P<0.05 or P<0.01),and negatively correlated with ALP(P<0.01).The overall hip BMD was positively correlated with smoking,AC,BMI,CAP,FC-P(P<0.05 or P<0.01).The overall BMD of the female lumbar spine is positively correlated with BMI and CAP(P<0.05 or P<0.01),but negatively correlated with age and ALP(P<0.05 or P<0.01).The overall hip BMD was positively correlated with BMI and CAP(P<0.05),and negatively correlated with age and ALP(P<0.05 or P<0.01).Multiple linear regression analysis shows that CAP is the influencing factor for overall lumbar BMD,while BMI is the influencing factor for overall hip BMD.Conclusions CAP is the influencing factor for overall lumbar BMD,while BMI is the influencing factor for overall hip BMD.
