Predictive value of serum C1q/tumor necrosis factor-related protein 12 with gestational diabetes mellitus in early pregnancy
10.3969/j.issn.1006-6187.2024.06.005
- VernacularTitle:孕早期血清C1q肿瘤坏死因子相关蛋白12预测妊娠期糖尿病的价值
- Author:
Xiuying MA
1
;
Luying CHEN
;
Miao ZHAO
Author Information
1. 518000 深圳市龙华区妇幼保健院孕产群体保健科
- Keywords:
C1q tumor necrosis factor related protein 12;
Gestational diabetes mellitus;
Predicted value;
Early pregnancy
- From:
Chinese Journal of Diabetes
2024;32(6):423-426
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the value of serum C1q tumor necrosis factor related protein 12(CTRP12)in early pregnancy in predicting gestational diabetes(GDM).Methods 182 pregnant women who underwent prenatal examinations in our department from March 2020 to October 2022 were selected,serum CTRP12 levels were measured at 6～14 weeks of pregnancy.At 24～28 weeks of pregnancy,they were divided into normal glucose tolerance(n=152,NGT)group and GDM group(n=30,GDM)based on OGTT results.The serum CTRP12 levels of the two groups were compared and its predictive value for GDM was analyzed.Results The incidence rate of GDM was 16.48%.Compared with NGT group,the age,pre pregnancy BMI,FPG and family history of diabetes in GDM group were significantly higher,and the serum level of CTRP12 was significantly lower(P<0.05).BMI before pregnancy,family history of diabetes,FPG and serum CTRP12 were the influencing factors of GDM.Receiver operating characteristic analysis showed that the AUC of serum CTRP12 for predicting GDM was 0.822(95%CI 0.759～0.885),the optimal cut-off value was 5.66 ng/ml,with the sensitivity 68.2%and the specificity 90.3%,respectively.Compared with the high level group of CTRP12,the incidence rate of GDM in the low level group of CTRP12 was significantly higher(P<0.05).Conclusions The serum CTRP12 level in GDM patients decreases in the early pregnancy.CTRP12 as an influencing factor may have certain predictive value for GDM.
