Association of serum L-carnitine and intestinal flora metabolites trimethylamine with gestational diabetes mellitus in mid-pregnancy women in Shanghai
10.3969/j.issn.1006-6187.2024.06.001
- VernacularTitle:上海地区孕中期女性血清左旋肉碱及其肠道菌群代谢产物三甲胺与妊娠期糖尿病相关性的研究
- Author:
Shiyin WU
1
;
Jie JIA
;
Jie ZHU
;
Kefeng YANG
;
Hui WU
;
Lingpeng LU
;
Yuhong LIU
;
Meiqin CAI
Author Information
1. 200025 上海交通大学公共卫生学院
- Keywords:
L-carnitine;
Trimethylamine;
Trimethylamine N-oxide;
Gestational diabetes mellitus
- From:
Chinese Journal of Diabetes
2024;32(6):401-407
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between serum L-carnitine and its related metabolites[trimethylamine(TMA)and trimethylamine N-oxide(TMAO)]levels and gestational diabetes mellitus(GDM)in the second trimester of pregnant women in Shanghai.Methods A case-control study was conducted in 280 pregnant women between 18 and 23 weeks of gestation from January 2018 to January 2021.Among them,134 cases of GDM were the case group(GDM),and 146 cases with normal blood glucose(BG)were the control group(Con).Serum L-carnitine,TMA and TMAO levels were quantified by ultra high performance liquid chromatography-mass spectrometry.Logistic regression analysis,stratified analysis and linear regression were used to explore the relationship between L-carnitine,TMA and TMAO levels and GDM and glucolipid metabolism.Results Serum L-carnitinelevelwas significantly lower in GDM group than that in Con group(P<0.01).After adjusting for confounders,logistic regression showed a 70%reduction in the risk of GDM in the group with highest tertile of L-carnitine compared with the group with lowest tertile(OR 0.30,95%CI 0.15～0.63).The risk of GDM decreased by 14%for each 1 μmol/L increase in serum L-carnitine(OR 0.86,95%CI 0.80～0.93).Serum L-carnitine was negatively correlated with 1 hPG(r=-0.21,P<0.01)and 2 hPG(r=-0.15,P<0.05),respectively,TMA was negatively correlated with 2 hPG(r=-0.21,P<0.01).Conclusions Higher serum L-carnitine level may be negatively associated with GDM.Serum L-carnitine and TMA levels were negatively correlated with blood glucose levels.
