Correlation between diabetic kidney disease and MRI of cerebral small vessel disease
10.3969/j.issn.1006-6187.2024.05.008
- VernacularTitle:糖尿病肾脏疾病与脑小血管病相关性的研究
- Author:
Mingyue TANG
1
;
Yinghua WU
Author Information
1. 611137 成都中医药大学医学与生命科学学院
- Keywords:
Diabetic kidney disease;
Cerebral small vessel disease;
Diabetes mellitus,type 2;
White matter hyperintensities
- From:
Chinese Journal of Diabetes
2024;32(5):357-360
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explored the correlation between diabetic kidney disease(DKD)and MRI of cerebral small vessel disease(CSVD).Methods 476 type 2 diabetes mellitus(T2DM)patients who were hospitalized in Chengdu University of Traditional Chinese Medicine Affiliated Hospital from January to August 2022 were selected and divided into simple T2DM group(UACR＜30 mg/g,n=330)and DKD group(UACR≥30 mg/g,n=146).General data,biochemical indicators and head MRI images of the two groups were compared.The correlation between DKD and CSVD and the influencing factors of white matter hyperintensities(WMHs)severity were analyzed.Results Age,DM duration,TG,Scr,HbA1c,SUA,cystatin C(Cys C),fibrinogen(Fib)and the incidence of hypertension were higher(P<0.05),while the ALT was lower in DKD group than in T2DM group(P<0.05).Spearman correlation analysis showed tha the presence of DKD was positively correlated with WMHs,lacunar infarction(LI)and brain atrophy(P<0.05).eGFR was negatively correlated with WMHs,LI and brain atrophy(P<0.05).Logistic regression analysis showed that age and HbA1c were the influencing factors for the severity of WMHs.Conclusion Patients with DKD have a higher incidence of CSVD,which may be related to worsening renal function.HbA1c may have predictive value for the severity of WMHs.
