Correlation analysis between renal ectopic fat deposition and early diabetic kidney disease
10.3969/j.issn.1006-6187.2024.05.007
- VernacularTitle:肾脏异位脂肪沉积与早期糖尿病肾脏疾病相关性的研究
- Author:
Jianjun HUA
1
;
Wenting YANG
;
Huaying HUANG
;
Yonghao PAN
;
Sisi WANG
;
Mingliang YING
Author Information
1. 321000 金华,浙江大学医学院附属金华医院放射科
- Keywords:
Diabetic kidney disease;
Ectopit fat deposition;
Magnetic resonance imaging;
Renal function
- From:
Chinese Journal of Diabetes
2024;32(5):352-356
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the value of iterative decomposition of water and fat with echo asymmetry and least-squares(IDEAL-IQ)sequence in evaluating the correlation between renal ectopic fat deposition and early diabetic kidney disease(DKD)in patients with diabetes mellitus(DM).Methods A total of 51 patients with T1DM or T2DM were enrolled in this study from the Endocrinology and Metabolism Department in Affiliated Jinhua Hospital,Zhejiang University School of Medicine during January 2022 to July 2023.All the patients were divided into two groups according to the results of urine albumin creatinine ratio(UACR):normal or slightly increased urinary micro albumin group(NAU,UACR<30 mg/g,n=27)and diabetic kidney disease group(DKD,UACR 30～300 mg/g,n=24).Meanwhile,55 healthy subjects in health examination were selected as control group(NC).Pearson correlation analysis was used to analyze the correlation between renal FF and other indicators.Logistic regression analysis was used to analyze the influencing factors of early DKD,and the diagnostic efficiency of renal FF for early DKD was analyzed by the ROC curve.Results Serum creatinine(Scr)and renal fat fraction(FF)value were higher in DKD group than in NC and NAU groups(P<0.05).Pearson correlation analysis showed that kidney FF were positively correlated with UACR and Hcy(P<0.05).Logistic regression analysis showed that after adjusting for confounding factors,renal FF was a contributing factor to early DKD.The ROC curve revealed that model 2 had the highest diagnostic efficiency,with AUC=0.801,sensitivity of 66.7%,specificity of 85.2%,accuracy of 80.0%,and a renal FF cut-off value was 2.46%.Conclusion IDEAL-IQ could non-invasively measure the renal fat content in DM patients,and the renal FF were significantly associated with DKD in early stage.
