Correlation between soluble α-Klotho levels with diabetic kidney disease and blood glucose control during continuous blood glucose monitoring
10.3969/j.issn.1006-6187.2024.05.005
- VernacularTitle:糖尿病肾脏疾病患者可溶性α-Klotho水平与持续血糖监测中血糖控制相关性的研究
- Author:
Linjuan LI
1
;
Junchen ZHENG
;
Mei ZHANG
;
Rui WANG
;
Ning YANG
Author Information
1. 716000 延安大学附属医院全科医学科
- Keywords:
Diabetic kidney disease;
Soluble α-Klotho;
Continuous glucose monitoring system;
Diabetes mellitus,type 2
- From:
Chinese Journal of Diabetes
2024;32(5):343-346
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the relationship between soluble α-Klotho(SKL)levels and continuous glucose monitoring(CGMS)-derived measures of glycemic management in diabetic kidney disease(DKD)patients.Methods A total of 140 T2DM patients admitted to the Department of General Medicine Affiliated Hospital of Yan'an University from May 2020 to May 2022 were selected and divided into two groups according to the levels of UACR:T2DM group(UACR<30 mg/g,n=60),DKD group(UACR≥30 mg/g,n=80)and 45 healthy persons(NC group)who received physical examination in the hospital during the same period were the NC group.Results The SKL level of DKD group was lower than that of T2DM group and NC group(P<0.05).Spearman correlation analysis showed that SKL was positively correlated with eGRF and TIR(P<0.01),and negatively correlated with Scr,UACR,CysC,β2-MG,FPG,HbA1c,MG,TAR and GMI(P<0.01).Multiple linear regression analysis showed that HbA1c and GMI were the influencing factors of SKL.Conclusion The level of SKL in DKD patients is correlated with HbA1c and GMI.
