Research Advance of Single Cell Sequencing Technology in Acute Myeloid Leukemia——Review

VernacularTitle:单细胞测序技术在急性髓系白血病中的应用研究进展
Author: Gen-Wang CHEN ¹ ; Lei LIU ; Chun-Mei FAN
Author Information

1. 福建医科大学附属第二医院临床医学检验中心,福建泉州 362000
Keywords: acute myeloid leukemia; single cell sequencing technology; intratumour heterogeneity; tumor microenvironment
From: Journal of Experimental Hematology 2024;32(6):1928-1932
CountryChina
Language:Chinese
Abstract: Acute myeloid leukemia (AML) is the most common and highly heterogeneous acute leukemia in adults. Despite the continuous optimization of prognostic risk stratification and treatment regimens,the overall long-term survival rate of AML patients remains low. The emergence of single cell sequencing (SCS) technology has overcome the defects of traditional sequencing to a certain extent,and realized the transformation of the research of malignant tumors from cell population level to single cell level. Consequently,it has been widely applied in many biological fields. This review mainly focuses on the application of SCS technology in the analysis of tumor heterogeneity,disease evolution,changes in tumor microenvironment,elucidation of drug resistance mechanisms and search for potential therapeutic targets in AML.