Application Analysis of Screening for Thalassemia in the Population of Childbearing Age in Quanzhou
10.19746/j.cnki.issn1009-2137.2024.06.031
- VernacularTitle:泉州地区育龄人群地中海贫血筛查的应用分析
- Author:
Mei-Zhen YAN
1
;
Xiao-Long LIU
;
Yuan-Bai WANG
;
Yu-Ying JIANG
;
Jian-Long ZHUANG
;
Geng WANG
;
Qian-Mei ZHUANG
Author Information
1. 泉州市妇幼保健院·儿童医院产前诊断中心,福建泉州 362000
- Keywords:
thalassemia;
MCV;
MCH;
HbA2;
ROC curve
- From:
Journal of Experimental Hematology
2024;32(6):1841-1847
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the application value of MCV,MCH and HbA2 in screening for thalassemia in the population of childbearing age in Quanzhou area,and to determine the optimal screening cut-off value of relevant indicators in this area. Methods:2725 couples of childbearing age were included in the study and underwent routine blood test,capillary hemoglobin electrophoresis,and α and β thalassemia gene test. Statistical methods were used to analyze the distribution of thalassemia genotypes,and compare the performance of MCV,MCH,and HbA2 in screening various types of thalassemia. According to the ROC curve,the best cut-off values of MCV,MCH and HbA2 in screening for thalassemia in this area were determined. Results:In this study,a total of 1801 thalassemia carriers were detected,including 1341 cases of α-thalassemia,420 cases of β-thalassemia,and 40 cases of αβ compound thalassemia. The most common genotypes of α-thalassemia and β-thalassemia were--SEA/αα and β654/βN,respectively. ROC curves were drawn to evaluate the performance of MCV,MCH and HbA2 in screening for α-thalassemia,mild β-thalassemia,αβ compound thalassemia,silent α-thalassemia,mild α-thalassemia,and intermediate α-thalassemia. The maximum areas under the curves (AUC) were 0.747,0.865,0.724,0.486,0.812,0.841;0.747,0.846,0.703,0.479,0.796,0.903;0.613,0.980,0.909,0.465,0.674,0.996,respectively;and the best cut-off values corresponding to the three screening indicators were 76.15fl,71.95fl,77.35fl,86.15fl,75.41fl,61.15fl;24.35pg,21.51pg,25.45pg,28.65pg,24.01pg,20.51pg;2.45％,3.05％,3.55％,3.25％,2.45％,1.65％,respectively. Conclusion:The levels of MCV,MCH and HbA2 are correlated with the phenotype of thalassemia,and the detection of these indicators is of great significance for the prevention and control of thalassaemia.
