Efficacy and Safety of Ixazomib Combined with Thalidomide and Dexamethasone in Treatment of Multiple Myeloma
10.19746/j.cnki.issn1009-2137.2024.05.023
- VernacularTitle:伊沙佐米联合沙利度胺和地塞米松治疗多发性骨髓瘤的疗效及安全性评价
- Author:
Xiang-Mei YAO
1
;
Zhi-Xiang LU
;
Jian-Hua RAO
;
Xiao-Li GAO
;
Qi WANG
;
Hai-Tao HE
Author Information
1. 云南省第一人民医院,昆明理工大学附属医院血液科,云南昆明 650032
- Keywords:
multiple myeloma;
ixazomib;
thalidomide;
dexamethasone;
efficacy
- From:
Journal of Experimental Hematology
2024;32(5):1450-1454
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the efficacy and safety of ixazomib combined with thalidomide and dexamethasone in the treatment of multiple myeloma(MM).Methods:The clinical data of 60 MM patients admitted to our center from January 2019 to June 2022 were analyzed retrospectively,including 43 newly diagnosed patients and 17 patients with recurrence and progression.All patients were treated with ixazomib combined with thalidomide and dexamethasone,and completed 2 to 7 treatment cycles.Results:The overall response rate(ORR)of all patients was 98.3％.Among them,53 patients completed 4 treatment cycles,and the ORR was 86.8％.Seventeen patients completed the whole treatment cycle,with curative effect reaching 88.2％achieving very good partial response and above,and 52.9％achieving complete response and above.Albumin and β2-microglobulin of all patients had been improved rapidly after treatment.The deadline was August 31,2022.The median follow-up time was 14(3-24)months,and overall survival(OS)rate was 86.67％.The OS rate of patients with recurrence and progression was significantly lower than that of newly diagnosed patients(P＜0.05).The most common adverse reaction of hematology was lymphopenia(53.3％),followed by anemia(33.3％).The most common non-hematological adverse reaction was fatigue(68.33％),followed by peripheral neuropathy(31.67％).Conclusion:Ixazomib combined with thalidomide and dexamethasone is effective in the treatment of MM,with good short-term efficacy,survival and safety.However,its long-term efficacy needs further observation.
