Clinical Study of Ibrutinib Combined with Venetoclax Regimen in the Treatment of Relapsed/Refractory Diffuse Large B-Cell Lymphoma
10.19746/j.cnki.issn1009-2137.2024.05.017
- VernacularTitle:伊布替尼联合维奈托克方案治疗复发难治性弥漫大B细胞淋巴瘤的临床研究
- Author:
Man YANG
1
,
2
;
Yan HUANG
;
Lu-Yao ZHU
;
Ling-Xiu ZHANG
;
You-Mei ZI
;
Xiu-Feng WANG
;
Yuan ZHANG
Author Information
1. 新乡医学院第一附属医院血液科
2. 新乡市淋巴瘤分子诊疗重点实验室,河南新乡 453100
- Keywords:
ibrutinib;
venetoclax;
relapsed/refractory;
diffuse large B-cell lymphoma;
NCCN-IPI
- From:
Journal of Experimental Hematology
2024;32(5):1414-1419
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the clinical efficacy of ibrutinib combined with venetoclax in the treatment of relapsed/refractory diffuse large B-cell lymphoma(R/R DLBCL),and to analyze the factors affecting efficacy and prognosis.Methods:Clinical data of 62 R/R DLBCL patients admitted to our hospital from August 2017 to July 2022 were retrospectively analyzed.All patients were treated with ibrutinib combined with venetoclax.The clinical efficacy and drug safety were evaluated.The effects of clinical features on short-term efficacy and overall survival(OS)were analyzed.Results:The objective response rate(ORR)of 62 patients was 48.39％.The extranodal lesions,intermediate-high/high risk of NCCN-IPI,intermediate-high/high risk of IPI,progression or recurrence time＜12 months were the risk factors affecting the short-term efficacy of chemotherapy in R/R DLBCL patients(all P＜0.05).The most common adverse effect was neutropenia(75.19％),and the incidence of grade Ⅱ-Ⅳ neutropenia was 52.71％.The l-year and 2-year OS rates of 62 patients were 48.51％and 31.56％,respectively,and the median OS time was 12 months.Multivariate analysis showed that objective remission after chemotherapy[HR=0.080(95％CI:0.028-0.235)]was a protective factor for OS in R/R DLBCL patients,and intermediate-high/high risk of NCCN-IPI[HR=4.828(95％CI:1.546-15.080)]was an independent risk factor affecting the prognosis of R/R DLBCL patients.Conclusion:Ibrutinib combined with venetoclax can be used as an effective treatment regimen for R/R DLBCL,and NCCN-IPI can be used as a prognostic indicator.Objective remission after chemotherapy is beneficial for R/R DLBCL patients to achieve better OS.
