Clinical Analysis of CD4+CD8-T-Cell Large Granular Lymphocytic Leukemia

VernacularTitle:CD4+CD8-T细胞大颗粒淋巴细胞白血病的临床分析
Author: Xiang-Xiang CHANG ¹ ; Shang-Biao SUN ; Yu-Wen LI ; Miao WANG ; Yan-Qing ZHU
Author Information

1. 临泉县人民医院血液内科,安徽临泉 236400
Keywords: CD4+CD8-T-cell large granular lymphocytic leukemia; clinical manifestations; treatment
From: Journal of Experimental Hematology 2024;32(5):1388-1393
CountryChina
Language:Chinese
Abstract: Objective:To investigate the clinical characteristics and treatment of patients with CD4+CD8-T-cell large granular lymphocytic leukemia(T-LGLL).Methods:The clinical manifestations,diagnosis and treatment of 1 case of CD4+CD8-T-LGLL patient were reported,and relevant literatures were reviewed.Results:The patient was a 70-year-old woman with slow clinical progress,mainly manifested by thrombocytopenia and myelodysplasia.The blood smear was mainly composed of large granular lymphocytes.Immunotyping and T-cell receptor gene rearrangement analysis showed that it was in line with T-LGLL.Partial remission(PR)was achieved through the treatment of cyclophosphamide(50 mg/d)combined with prednisone(gradually reduced and stopped later).Conclusion:CD4+CD8-T-LGLL is very rare in clinical practice,and its clinical manifestations are different from those of CD4-CD8+T-LGLL.