Effect of Collagen Peptides on Function of Mouse T Lymphocytes under Simulated Microgravity
10.19746/j.cnki.issn1009-2137.2024.04.043
- VernacularTitle:胶原蛋白肽对模拟微重力条件下鼠T淋巴细胞功能的改善作用
- Author:
Shao-Yan SI
1
;
Ya-Ya QIN
;
Ying-Ying WU
;
Xiao-Yu MA
;
Ying SHANG
;
Shu-Jun SONG
;
Yan-Chuan GUO
Author Information
1. 战略支援部队特色医学中心综合基础实验研究室(研究部二室),北京 100101
- Keywords:
collagen peptide;
simulated microgravity;
lymphocyte;
cell proliferation;
cytokine
- From:
Journal of Experimental Hematology
2024;32(4):1258-1263
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To understand the effect of collagen peptides on the function of mouse lymphocytes under simulated microgravity.Methods:The splenocytes of mice were isolated,and the rotary cell culture system was used to simulate the microgravity.The T lymphocytes were stimulated with mitotic agents,concanavalin A(ConA),and the cells were treated with different concentrations of collagen peptides.The proliferation of lymphocytes and the levels of cytokines in the supernatant were detected.Results:Simulated microgravity could inhibit the proliferation of spleen T lymphocytes and decrease the level of cytokines in the supernatant.Collagen peptides could promote the lymphocyte proliferation and cytokine production in cells cultured under simulated microgravity.Conclusion:Collagen peptides may attenuate the inhibitory effect of simulated microgravity on T lymphocytes by regulating the cell proliferation and the secretion of cytokines.
