Clinical Analysis of Epstein-Barr Virus Infection after Allogeneic Hematopoietic Stem Cell Transplantation
10.19746/j.cnki.issn1009-2137.2024.04.038
- VernacularTitle:异基因造血干细胞移植术后EB病毒感染的临床分析
- Author:
Lan-Xiang LIU
1
;
Jing WANG
;
Li WANG
;
Lin LIU
;
Xin WANG
;
Hong-Bin ZHANG
;
Xiao-Qiong TANG
;
Yi-Ying XIONG
Author Information
1. 重庆医科大学附属第一医院血液内科,重庆 400016
- Keywords:
allogeneic hematopoietic stem cell transplantation;
EBV infection;
risk factors
- From:
Journal of Experimental Hematology
2024;32(4):1217-1223
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the risk factors of Epstein-Barr virus(EBV)infection after allogeneic hematopoietic stem cell transplantation(allo-HSCT)and its impact on survival.Methods:The clinical data of 347 patients who underwent their first allo-HSCT in our hospital from January 2014 to June 2021 were retrospectively analyzed.Patients were divided into EBV(n=114)and Non-EBV(n=233)groups according to whether they were infected with EBV.The incidence of EBV infection after allo-HSCT was calculated,and the risk factors of EBV infection were analyzed.Results:A total of 114(32.8％)patients presented EBV infection(all peripheral blood EBV-DNA were positive).EBV infection occurred in 88 patients within 100 days after transplantation,which accounted for 77.2％of all patients with EBV infection.5 cases(1.44％)were confirmed as post-transplant lymphoproliferative disorder(PTLD).The median onset time of patients was 57(7-486)days after transplantation.Multivariate analysis showed that the use of ATG/ATG-F,occurrence of CMV viremia,and grade Ⅲ-Ⅳ aGVHD were risk factors for EBV infection.Furthermore,compared to BUCY,the use of intensified preconditioning regimens containing FA/CA was significantly increased the risk of EBV infection.Conclusion:EBV infection is a common complication after allo-HSCT.Intensified preconditioning regimens,use of ATG/ATG-F,CMV viremia and grade Ⅲ to Ⅳ aGVHD increase the risk of EBV infection after allo-HSCT.
