Research Progress of Bispecific Antibodies in Treatment of Multi-ple Myeloma——Review
10.19746/j.cnki.issn1009-2137.2024.03.046
- VernacularTitle:双特异性抗体在多发性骨髓瘤治疗中的研究进展
- Author:
Fan HAN
1
;
Xue-Peng ZHANG
;
Ya-Ming XI
Author Information
1. 兰州大学第一临床医学院
- Keywords:
multiple myeloma;
bispecific antibodies;
immunotherapy
- From:
Journal of Experimental Hematology
2024;32(3):952-956
- CountryChina
- Language:Chinese
-
Abstract:
Multiple myeloma(MM)is an incurable malignant plasma cell diseases,the incidence of which is increasing year by year.The application of immunomodulators drugs,proteasome inhibitors,anti-CD38 antibodies,CAR-T,and HSCT have significantly improved the prognosis of patients with MM,however new therapeutic tools need to be developed to improve the prognosis of patients with relapsed/refractory after conventional regimens treatment.Bispecific antibodies are a novel immunotherapeutic approach that generates immune synapses by binding to targets on malignant plasma cells and cytotoxic immune effector cells(T cells/natural killer cells),leading to T/NK cells activation and malignant plasma cell lysis.Several preclinical and phase Ⅰ clinical studies have shown good efficacy,bringing new possibilities for patients with relapsed/refractory MM to improve their prognosis in the future in combination with the rest of the treatment options.This article summarizes the classification of bispecific antibodies developed in recent years,and the results of preclinical and clinical trials,which will provide some reference for treating MM.
