Expression of MiR-144/451 in Different Types of Anemia
10.19746/j.cnki.issn1009-2137.2024.03.026
- VernacularTitle:microRNA-144/451在不同类型贫血性疾病中的表达
- Author:
Fan YANG
1
;
Ling LING
;
Ya-Ying HOU
;
Lan YANG
;
Mei SUN
;
Fang-Fang WANG
;
Duo-Nan YU
Author Information
1. 扬州大学医学院,江苏省非编码RNA基础与临床转化重点实验室,江苏扬州 225009
- Keywords:
miR-144;
miR-451;
anemia;
correlation analysis
- From:
Journal of Experimental Hematology
2024;32(3):825-830
- CountryChina
- Language:Chinese
-
Abstract:
Objective:io investigate the expression level and clinical correlation of microRNA-144/451 gene cluster(miR-144/451)in different types of anemia.Methods:The peripheral blood of patients with aplastic anemia(AA),myelodysplastic syndrome(MDS)and diffuse large B-cell lymphoma(DLBCL)who had been diagnosed with anemia for the first time and after chemotherapy were collected.The expression levels of miR-144 and miR-451 were measured by RT-qPCR,and the correlation between the expression levels of miR-144 and miR-451 and routine laboratory indexes was analyzed by Spearman correlation analysis.Results:The expression levels of miR-144 and miR-451 in the peripheral blood of AA and MDS patients were significantly lower than those in normal controls(all P＜0.0 1).No statistical differences were observed in the expression level of miR-144 in three subgroups of DLBCL patients(P＞0.05),while the expression level of miR-451 in peripheral blood of three subgroups of DLBCL patients were significantly higher than those in normal controls(all P＜0.05).Correlation analysis showed that the expression levels of miR-144 and miR-451 in AA patients were positively correlated with red blood cell distribution width-coefficient of variation(RDW-CV)(r=0.629,0.574).There were no significant correlations between the expression levels of miR-144 and miR-451 and laboratory parameters in MDS and DLBCL patients.Conclusion:Different types of anemia disorders have varying levels of miR-144 and miR-451 expression,which is anticipated to develop into a secondary diagnostic and differential diagnostic indicator for clinical anemia diseases.
