Expression and Clinical Significance of LINC00475 in Multiple Myeloma
10.19746/j.cnki.issn1009-2137.2024.03.020
- VernacularTitle:LINC00475在多发性骨髓瘤中的表达与临床意义
- Author:
Ling LU
1
;
Dan GUO
;
Le-Min HONG
;
Yu-Wen JIANG
;
Hong-Ming FAN
;
Chun-Qun HUANG
;
Jin-Feng LU
;
Jie CHEN
;
Hong-Hui XU
;
Hong-Ming HUANG
Author Information
1. 南通大学附属医院血液内科,江苏南通 226001
- Keywords:
multiple myeloma;
LINC00475;
long non-coding RNA
- From:
Journal of Experimental Hematology
2024;32(3):789-793
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the relative expression level and clinical significance of LINC00475 in serum of patients with multiple myeloma(MM).Methods:The expression of LINC00475 in serum of 108 MM patients and five MM cell lines including RPMI 8226,NCI-H929,U266,OPM2 and CAG were detected by real-time fluorescence quantitative PCR.The diagnostic value of LINC00475 in MM was evaluated by receiver operating characteristic(ROC)curve analysis.The correlation of LINC00475 with patients'characteristics was analyzed.Results:Compared with control groups,the expression of LINC00475 was up-regulated in serum of MM patients and MM cell lines(all P＜0.05).ROC curve analysis showed that the optimal cut-off value of LINC00475 was 262.4,the area under curve(AUC)was 0.924(95％CI:0.884-0.964),and sensitivity and specificity was 83.3％and 91.7％,respectively,which indicated that LINC00475 had good evaluation value in MM patients.Compared with low-LINC00475 expression group,patients in high-LINC00475 expression group had higher levels of β2-microglobulin(β2-MG)and Cystatin C(Cys-C)but lower albumin(ALB)(all P＜0.05).Compared with MM patients with International Staging System(ISS)stage I,the expression level of LINC00475 was significantly higher in patients with stage Ⅱ and Ⅲ(both P＜0.05).Conclusion:LINC00475 is helpful to distinguish MM patients from healthy adults,which is correlated with the prognostic indicators such as β2-MG,ALB,and ISS stage.
