The Effecacy and Safety of Daratumumab Based Regimens in Relapsed/Refractory Multiple Myeloma:A Single-Center Real-World Data Analysis
10.19746/j.cnki.issn1009-2137.2024.03.016
- VernacularTitle:达雷妥尤单抗为基础的方案治疗复发难治性多发性骨髓瘤的有效性及安全性:单中心真实世界数据
- Author:
Han-Yan ZENG
1
;
Zhi-Juan LIN
;
Zhi-Feng LI
;
Long LIU
;
Man-Man DENG
;
Bing XU
Author Information
1. 厦门大学第一附属医院血液科,厦门大学医学院血液研究所,厦门市恶性血液病诊断与治疗重点实验室,福建厦门 361003
- Keywords:
relapse/refractory multiple myeloma;
daratumumab;
efficacy;
stem cell collection and engraftment
- From:
Journal of Experimental Hematology
2024;32(3):763-767
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the efficacy and safety of daratumumab based regimens in relapse and/or refractory multiple myeloma(RRMM)in the real world,as well as the impact of daratumumab on stem cell collection and engraftment.Methods:The clinical data of patients with RRMM who received daratumumab in hematology department of the First Affiliated Hospital of Xiamen University from February 2019 to March 2023 and had evaluable efficacy were retrospective analysis.Results:All 43 RRMM patients were treated with daratumumab-based combination regimens,including Dd,DVd,DRd,Dkd,DId,and Dara-DECP.With median follow-up time 10.1(2.1-36.6)months,the best overall response rate(ORR)was 74.4％and a best complete response rate(CR)was 25.6％.1-year overall survival rate(OS)was 84.5％.The most common severe hematologic adverse events(Grade＞3)are 3/4 grade leukopenia(18.6％),and the most common severe non-hematologic adverse events were infusion-related reactions(IRRs,20.9％)and infections(7.0％).Multivariate prognostic analysis showed that extramedullary infiltration was an independent adverse prognostic factor affecting OS(P=0.004).The use of daratumumab has no effect on stem cell collection,or engraftment.Conclusion:Daratumumab is safe and effective in RRMM.
