Pathogenesis and Therapeutic Prospects of Chronic Graft-Versus-Host Disease

VernacularTitle:慢性移植物抗宿主病的发病机制和治疗前景
Author: Shu-Hui XU ¹ ; Yan MAN ; Jin-Lian ZHAO ; Ya-Jie WANG
Author Information

1. 昆明理工大学医学院,云南昆明 650500
Keywords: chronic graft-versus-host disease; allogeneic hematopoietic stem cell transplantation; immune cells; pathogenesis; therapeutic prospects
From: Journal of Experimental Hematology 2024;32(2):647-652
CountryChina
Language:Chinese
Abstract: Chronic graft-versus-host disease(cGVHD)is one of a major complication that affecting the long-term survival and living quality of patients after allogeneic hematopoietic stem cell transplantation,with the incidence of 30％-70％.Unlike acute GVHD,cGVHD involves a large number of immune cells and cytokines in addition to T cell,which is activated abnormally by the donor,and cytokine storms,which characterized by infiltration of donor lymphocytes and damage to host target organ.Recent studies have further made progress in targeting related immune cells and cytokines.In this review,the pathogenesis and therapeutic prospects of cGVHD were summarized from the perspectives of classical innate and adaptive immunity.