Subjective Cognitive Decline and Alzheimer's Disease Spectrum Disorder.
10.12779/dnd.2017.16.2.40
- Author:
Yun Jeong HONG
1
;
Jae Hong LEE
Author Information
1. Department of Neurology, Dong-A University College of Medicine, Busan, Korea.
- Publication Type:Review
- Keywords:
subjective cognitive decline;
Alzheimer's disease;
biomarker;
preclinical stage
- MeSH:
Alzheimer Disease*;
Follow-Up Studies;
Health Services Needs and Demand;
Neuropsychological Tests;
Outcome Assessment (Health Care);
Pathology
- From:Dementia and Neurocognitive Disorders
2017;16(2):40-47
- CountryRepublic of Korea
- Language:English
-
Abstract:
Subjective cognitive decline (SCD) represents subjective complaints about cognitive decline in the absence of objective impairment in neuropsychological tests. Recently, growing evidence has suggested that SCD might be the first symptomatic stage of Alzheimer's disease (AD) spectrum disorders. However, SCD is a heterogeneous condition mixed with AD and non-AD related conditions. Hence, refinement of evidence from previous reports and standardization of the concept about SCD are needed to define appropriate target population with AD pathology. In this article, we review previous studies involving subjects with SCD, the new proposed research criteria, and characteristics of SCD in the aspect of preclinical AD. Biomarker status of SCD is also addressed. Future researches on SCD require a longitudinal follow-up with sufficient biomarker studies and proper outcome measures.
