Correlation Analysis of Peripheral Blood B Cell Count with Clinical Features and Prognosis in Patients Newly Diagnosed with Diffuse Large B-Cell Lymphoma
10.19746/j.cnki.issn1009-2137.2024.02.021
- VernacularTitle:初诊弥漫大B细胞淋巴瘤患者外周血B细胞计数与临床特征及预后的相关性分析
- Author:
Tian LU
1
,
2
;
Hao MI
;
Dan-Dan ZHAO
;
Shui-Ge YANG
;
Yun-Wen BU
;
Fang ZHANG
;
Wen-Ming CHEN
;
Dao-Ping SUN
Author Information
1. 济宁医学院临床医学院,山东济宁 272013
2. 济宁市第一人民医院血液内科,山东济宁 272011
- Keywords:
diffuse large B-cell lymphoma;
B cells;
peripheral blood;
prognosis
- From:
Journal of Experimental Hematology
2024;32(2):458-465
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the correlation between peripheral blood B cell count and clinical features and prognosis of patients with newly diagnosed diffuse large B-cell lymphoma(DLBCL).Methods:The relationship of peripheral blood B cell count with clinical features,laboratory indexes and prognosis in 67 patients with newly diagnosed DLBCL was retrospectively analyzed.Results:Patients were divided into low B-cell count group(B cell＜0.1 × 109/L,n=34)and high B-cell count group(B cell≥0.1 × 109/L,n=33)according to the median B cell count values.Compared with the high B cell count group,the low B cell count group had a higher proportion of patients with Lugano stage Ⅲ-Ⅳ,elevated LDH,elevated β2-MG and IPI score 3-5 and increased CRP(P=0.033,0.000,0.023,0.001,0.033).The peripheral CD3+and CD4+cell counts of patients in the low B cell count group were significantly lower than those in the high B cell count group(P=0.010,0.017).After initial treatment,overall response rate(ORR)and complete remission(CR)rate in high B cell count group were significantly higher than those in low B cell count group(P=0.032,0.013).The median follow-up time of patients was 23(2-77)months,progression-free survival(PFS)and overall survival(OS)of patients in the high B cell count group were significantly better than those in the low B cell count group(P=0.001,0.002).Univariate analysis showed that pretreatment low B cell count in the peripheral blood was associated with shortened PFS and OS(HR=4.108,P=0.002;HR=8.218,P=0.006).Multivariate analysis showed that low B cell count was an independent prognostic factor for shortened PFS(HR=3.116,P=0.037).Conclusion:Decreased peripheral blood B cell count in newly diagnosed DLBCL patients is associated with high-risk clinical features and may affect the efficacy of immunochemotherapy,which is associated with poor clinical prognosis.
