Research Progress of NK Cell Therapy in Multiple Myeloma Treat-ment

VernacularTitle:NK细胞疗法在多发性骨髓瘤治疗中的研究进展
Author: Fan HAN ¹ ; Ya-Ming XI
Author Information

1. 兰州大学第一临床医学院
Keywords: multiple myeloma; hematopoietic microenvironment; NK cell; research progress
From: Journal of Experimental Hematology 2024;32(1):297-301
CountryChina
Language:Chinese
Abstract: Multiple myeloma(MM)is a hematologic neoplasm characterized by malignant proliferation of monoclonal plasma cells in the bone marrow.NK cells,a class of innate lymphocytes with potent natural killer activity,are capable of recognizing and destroying tumor cells and virally infected cells,and have attracted attention as a potential anticancer therapy.In patients with MM,NK cells are suppressed in number and function,resulting in reduced immune surveillance and clearance of myeloma cells.Restoring or enhancing the killing effect of NK cells on myeloma cells is an important strategy for MM immunotherapy,and some progress has been made in clinical trials targeting NK cell-related therapies.This article reviews the research progress on the applications prospects of NK cell in MM immunotherapy.