Research progress of immune response mechanisms and prevention and control of porcine circovirus type 2
10.16303/j.cnki.1005-4545.2024.11.24
- VernacularTitle:猪圆环病毒2型免疫应答机制及防控进展
- Author:
Yinming MAO
1
;
Deyuan TANG
;
Zhiyong ZENG
;
Bin WANG
;
Tao HUANG
;
Song HE
;
Piao ZHOU
;
Zhengbo LIAO
;
Shenglin YUAN
;
Xu CHEN
Author Information
1. 贵州大学 动物科学学院,贵州贵阳 550025
- Keywords:
porcine circovirus type 2;
signal path;
immune escape;
innate immunity;
adaptive immu-nity
- From:
Chinese Journal of Veterinary Science
2024;44(11):2483-2489
- CountryChina
- Language:Chinese
-
Abstract:
Porcine circovirus type 2(PCV2)is the main pathogen causing porcine circovirus related diseases.PCV2 infection in pigs may lead to porcine dermatitis and nephrotic syndrome(PDNS)and weaned piglets multiple system failure syndrome(PMWS),etc.At present,the pathogenic mechanism is not fully understood.PCV2 is a single strand of negative link DNA,which can cause immune suppression in the body and lead to increased secondary susceptibility,which has a syner-gistic effect with various pig diseases and brings major economic losses to the pig industry.Al-though there are commercial vaccines,the prevention of vaccines has certain limitations and there is no effective drug treatment so far,an outbreak will threaten people's life and health and public safety,resulting in significant economic losses.In order to understand the latest progress of PCV2 escape mechanism and prevention and control,this paper summarizes the inhibition of interferon production,regulation of apoptosis,regulation of autophagy,regulation of pyroptosis and inflam-matory response,evasion of adaptive immune response,and prevention and control of PCV2,in or-der to provide new theoretical ideas for the research and prevention and control of PCV2.
