Advance in pyroptosis in animals infectious diseases
10.16303/j.cnki.1005-4545.2024.09.29
- VernacularTitle:细胞焦亡在动物传染性疾病中的研究进展
- Author:
Ruxin ZHANG
1
;
Huimei LIANG
;
Huan ZENG
;
Chen GUO
;
Jingyi QI
;
Jiarui PAN
;
Beining WU
;
Qiyi CHEN
;
Houhui SONG
;
Wei WANG
;
Jinghua ZHAO
Author Information
1. 浙江农林大学动物科技学院·动物医学院,浙江省畜禽绿色生态健康养殖应用技术研究重点实验室/动物健康互联网检测技术浙江省工程实验室/动物医学与健康管理浙江省国际科技合作基地/中澳动物健康大数据分析联合实验室,浙江 杭州 311300
- Keywords:
pyroptosis;
inflammasome;
zoonosis;
molecule mechanism
- From:
Chinese Journal of Veterinary Science
2024;44(9):2072-2080
- CountryChina
- Language:Chinese
-
Abstract:
Pyroptosis is a programmed death of inflammatory cells triggered by pathogen invasion,dependent on caspase activation,through both classical and non-classical pyroptosis pathways.Cell pyroptosis is related to the occurrence and development of a variety of animal infectious diseases caused by microbial infection.After microorganisms invading,cells are stimulated by pathology-re-lated molecular patterns,causing strong immune response,stimulating inflammatory signaling pathways,and then activating inflammasome,leading to pyroptosis.The immune system has e-volved multiple mechanisms to fight microbial infections and regulate inflammatory responses.The innate immune system,by recognizing microbial molecules in pathogens and responding quickly by producing inflammasome and activating pyroptosis,helps clear pathogens to prevent infection and maintain the normal functioning of the body.A thorough study of the pathogenesis and immune es-cape mechanism of cell pyroptosis in animal infectious diseases will provide a new direction for the treatment of animal infectious diseases.
