Role of SIRT2 in LPS induced acute kidney injury in mice

VernacularTitle:SIRT2在LPS诱导小鼠急性肾损伤中的作用及机制
Author: Qi HAN ¹ ; Huanmin YANG ; Shize LI ; Bin XU ; Jingjing LU ; Wanqun XING ; Xu ZHANG
Author Information

1. 黑龙江八一农垦大学动物科技学院,黑龙江大庆 163319
Keywords: SIRT2; acute kidney injury; inflammation; oxidative stress; mice
From: Chinese Journal of Veterinary Science 2024;44(9):1976-1981
CountryChina
Language:Chinese
Abstract: Sirtuin2(SIRT2)is an NAD+dependent histone deacetylase that plays a key role in maintaining cellular REDOX potential and modulating pro-inflammatory immune responses.How-ever,its role in acute kidney injury(AKI)has not been proven.To explore the role of SIRT2 in AKI,AKI models were constructed in wild-type(WT)and SIRT2 knockout(SIRT2-/-)mice by injection of lipopolysaccharide(LPS).HE results showed that kidney damage in SIRT2-/-mice was more significant than that in LPS treated WT mice.qRT-PCR and Western blot results showed that more significant changes in inflammatory genes,proteins and oxidative stress proteins in SIRT2-/-mice.The results suggest that SIRT2 deficiency exacerbates LPS induced AKI.