Progress inevasion mechanisms of innate immunity by porcine reproductive and re-spiratory syndrome virus
10.16303/j.cnki.1005-4545.2024.08.33
- VernacularTitle:猪繁殖与呼吸综合征病毒天然免疫逃逸机制研究进展
- Author:
Aijun LIU
1
;
Xiaobing HUANG
;
Hangjian ZHANG
;
Caiqing ZHOU
;
Huiting AN
;
Chuangliang ZHANG
Author Information
1. 浙江省动物疫病预防控制中心,浙江杭州 311199
- Keywords:
PRRSV;
innate immunity;
immune evasion;
IFN-Ⅰ;
autophagy;
programmed cell death;
Non-coding RNAs
- From:
Chinese Journal of Veterinary Science
2024;44(8):1831-1840
- CountryChina
- Language:Chinese
-
Abstract:
Innate immunity is the front line of the antiviral immune response and the bridge to a-daptive immunity.Porcine reproductive and respiratory syndrome virus(PRRSV)has evolved mul-tiple strategies to evade the host's innate immunity and thus establish persistent infections,which is one of the biggest obstacles to control PRRSV infection.In antiviral innate immunity,type Ⅰ in-terferons,interferon-stimulated genes(ISGs),and other antiviral proteins are the main perform-ers,cellular autophagy and programmed cell death are important components,noncoding RNAs are key regulators.Studies on evasion mechanisms of innate immune by PRRSV have emerged in re-cent years,greatly expanding our understandings of the PRRSV-host interaction network.In this paper,we outline the latest researches on PRRSV inhibition of type Ⅰ interferon production and its signaling transduction as well as antagonism of ISGs and other antiviral proteins,and focus on summarizing the researches on PRRSV evade the innate immunity through the modulation of cel-lular autophagy,programmed cell death,and non-coding RNAs,with a view to providing ideas for subsequent research and anti-PRRSV vaccine and drug development.
