Role and mechanism of butyric acid in hamster leptospirosis
10.16303/j.cnki.1005-4545.2024.08.22
- VernacularTitle:短链脂肪酸丁酸增强巨噬细胞预防问号钩端螺旋体的急性感染
- Author:
Xi CHEN
1
;
Xufeng XIE
;
Xin LIU
;
Jiuxi LIU
;
Wenlong ZHANG
;
Yongguo CAO
Author Information
1. 吉林大学动物医学学院,吉林长春 130062
- Keywords:
butyric acid;
leptospirosis;
ROS;
macrophage;
gut microbiota
- From:
Chinese Journal of Veterinary Science
2024;44(8):1743-1748
- CountryChina
- Language:Chinese
-
Abstract:
Leptospirosis is a global natural zoonotic infectious disease.Research shows that short-chain fatty acids,metabolites of gut microbiota,are involved in host immune regulation and affect disease progression.This experiment was conducted to investigate the role of short-chain fatty acids in leptospirosis.The results showed that supplementation of short-chain fatty acid butyric acid could significantly improve the survival rate of leptospirosis in hamsters.In vitro experiments showed that butyric acid treatment inhibited the expression of Cat and Gsr genes in macrophages after infection with Leptospira,but enhanced the expression of NOX1 and NOX4 genes.At the same time,butyric acid treatment enhanced macrophage ROS levels after leptospirosis infection,and high levels of ROS enhanced the bactericidal function of macrophages.In vivo experiments al-so confirmed that butyric acid protects hamsters against acute leptospirosis by regulating ROS production.Collectively,the short-chain fatty acid butyric acid,a metabolite of gut microbiota,en-hances the bactericidal function of macrophages by regulating ROS expression,thereby protecting the host against leptospirosis.
