CD24 Expression in Gastric Adenocarcinoma Is Associated with Tumor Invasiveness.
- Author:
Kyeong Cheon JUNG
1
;
Jae Nam SEO
;
Tae Woon KIM
;
Young Mi CHOI
;
Kwon Ik OH
;
Hun Ho SONG
;
Hyung Sik SHIN
;
Young Euy PARK
Author Information
1. Departments of Pathology, Hallym University College of Medicine, Chuncheon, Korea. yepark@hallym.ac.kr
- Publication Type:Original Article
- Keywords:
CD24 antigen;
Stomach neoplasms;
Neoplasm invasiveness;
Matrix metalloproteinase-2
- MeSH:
Adenocarcinoma*;
Adenoma;
Animals;
Antigens, CD24;
B-Lymphocytes;
Glycoproteins;
Hot Temperature;
Humans;
Matrix Metalloproteinase 2;
Mice;
Neoplasm Invasiveness;
Neurons;
Neutrophils;
Stomach Neoplasms;
Thymocytes
- From:Korean Journal of Pathology
2004;38(6):388-393
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: CD24, also referred to as the heat stable antigen in mice, is a glycosyl phosphatidylinositol- linked glycoprotein expressed by thymocytes, B cells, neutrophils and immature neuronal cells. It has been recently observed in a variety of human malignancy. Here, we demonstrated the expression of CD24 in gastric adenocarcinomas. METHODS: A total of 40 gastric adenocarcinomas and 20 tubular adenomas were immunohistochemically examined for the expression of CD24 and matrix metalloproteinase-2 (MMP-2) proteins. The immunoreactivity of CD24 was semiquantitatively scored (0, 1+, 2+) and compared with clinicopathologic variables and MMP-2 expression in tumor cells. RESULTS: CD24 was rarely expressed in normal gastric tissue and not expressed in tubular adenoma. In contrast, a moderate/strong expression (2+) of CD24 was observed in 25% of gastric adenocarcinomas, and 30% cases showed a weak CD24 staining (1+). Moreover, CD24 expression was significantly correlated with the depth of tumor invasion and MMP-2 expression. CONCLUSION: These results suggest that the aberrant expression of CD24 in gastric adenocarcinomas might be associated with tumor progression and invasiveness.
