Research progress on molecular mechanism of transmembrane internalization of CSFV and prevention and control of CSF
10.16303/j.cnki.1005-4545.2024.07.27
- VernacularTitle:猪瘟病毒跨细胞膜内化分子机制及猪瘟的防控研究进展
- Author:
Hong ZOU
1
,
2
;
Peng CHENG
;
Jianhua GUO
;
Gan LUO
;
Shilei HUANG
Author Information
1. 重庆三峡职业学院动物科技学院,重庆万州 404100
2. 西南大学动物医学院,重庆荣昌 402460
- Keywords:
classical swine fever virus;
transcellular membrane internalization;
molecular mechanism
- From:
Chinese Journal of Veterinary Science
2024;44(7):1556-1562
- CountryChina
- Language:Chinese
-
Abstract:
Classical swine fever(CSF),caused by classical swine fever virus(CSFV),is a severe in-fectious disease characterized by high fever and extensive bleeding,which is listed as a mandatory report disease by WOAH.As a single-stranded RNA envelope virus,CSFV has evolved a strategy for attachment and entry to the cell in the process of adapting to external environmental pressure.H owever,the underlying molecular mechanism remains largely unknown.Studies have shown that CSFV is mainly internalized through clathrin-mediated cross-membrane internalization and exists in the form of endosomes in the cytoplasm.Under certain conditions,the endosomal membrane fu-sion releases the genome for viral proliferation.At the same time,CSFV also depends on the inter-action with host proteins to inhibit the synthesis and secretion of host interferon,regulate host cell apoptosis,autophagy,pyroptosis and inflammatory response,and other life activities to evade the host's natural immunity,thus promoting the further replication of the virus in the host.However,the underlying specific mechanism needs further studying.Here,we summarize the molecular mechanism of CSFV internalization across cell membranes and the challenges of CSF prevention and control,with a view to providing theoretical assistance for CSF purification.
