Epidemiology and genetic evolution of African swine fever virus:Variations and constants
10.16303/j.cnki.1005-4545.2024.07.26
- VernacularTitle:非洲猪瘟病毒的流行与遗传演化:变与不变
- Author:
Shengmei CHEN
1
,
2
;
Tao WANG
;
Zhanhao LU
;
Jing LAN
;
Rui LUO
;
Qiang FU
;
Yuan SUN
;
Huaji QIU
Author Information
1. 佛山科学技术学院生命科学与工程学院,广东佛山 528231
2. 中国农业科学院哈尔滨兽医研究所动物疫病防控全国重点实验室,黑龙江哈尔滨 150069
- Keywords:
African swine fever;
African swine fever virus;
mutation;
recombination;
genetic evolu-tion;
vaccine
- From:
Chinese Journal of Veterinary Science
2024;44(7):1545-1555
- CountryChina
- Language:Chinese
-
Abstract:
African swine fever(ASF)is a highly contagious and pathogenic disease affecting both domestic and wild pigs,which is caused by African swine fever virus(ASFV).In European epidem-ics,low-virulence strains of ASFV,which do not have hemadsorbing properties,have been identi-fied.Following the identification of highly virulent genotype Ⅱ ASFV strains in China in 2018,subsequently,low-virulence strains of genotype Ⅱ and genotype Ⅰ emerged.Recombination be-tween genotypes Ⅰ and Ⅱ has also led to the occurrence of high-virulence strains.This indicates a complex and diverse genetic evolution of ASFV during the epidemiological transmission,which po-ses significant challenges for vaccine development and disease surveillance.Here,we provide an o-verview of the novel epidemiological characteristics of ASFV,with a focus on genetic variations and pathogenic differences during the outbreaks of ASF.We also explore how ASFV genetic varia-tions impact immune escape and pathogenicity of the virus,and the challenges they pose for vac-cine development,disease diagnosis,and surveillance.The aim of this review is to enhance our un-derstanding of the genetic evolution and mutation mechanisms of ASFV,providing a theoretical basis for the development of vaccines and research on diagnostic technologies.
