Correlation between serum PEDV S1 IgG antibody levels and neutralizing antibody levels in sows
10.16303/j.cnki.1005-4545.2024.07.04
- VernacularTitle:母猪血清PEDV S1 IgG抗体水平与中和抗体水平的相关性
- Author:
Yaoyao PAN
1
;
Junbo WANG
;
Shiqing XIE
;
Meiting LIN
;
Ye LUO
;
Jin ZHENG
;
Chengcai HU
;
Xinglong YU
Author Information
1. 湖南农业大学动物医学院,湖南长沙 410128
- Keywords:
porcine epidemic diarrhea virus;
S1 protein;
IgG;
neutralizing antibody
- From:
Chinese Journal of Veterinary Science
2024;44(7):1367-1372
- CountryChina
- Language:Chinese
-
Abstract:
The aim of this study was to investigate the correlation between porcine epidemic diar-rhea virus(PEDV)S1 IgG antibody levels and neutralizing antibody potency in sow sera.Sera from 5 PEDV-infected farms with a clear immune background,5 non-infected farms and 5 infected farms with an unclear immune background,and sera from return-fed reserve pigs,totaling 716 copies,were collected and measured,and the correlation between PEDV S1 IgG antibodies and neutralizing antibodies was analyzed.The results showed that the PEDV S1 IgG and neutralizing antibodies of sow sera showed highly significant positive correlation,the correlation coefficient was 0.892(P＜0.000 1).Previous studies have shown that the level of PEDV neutralizing antibodies in sow serum correlates with the ability of piglets'maternal antibodies to resist PEDV infection.Therefore,the a-bility of maternal antibodies against PEDV in piglets can be evaluated by detecting PEDV S1 IgG antibodies in the serum of sows.In 10 PEDV-infected farms,the neutralizing antibodies to PEDV in the sera of sows after immunization were generally high,and the S1 IgG antibodies were also high,and their S/P values were higher than 3.5 in 66.9％of the farms(347/519),and the highest anti-body levels were found in the four farms in which PED did not occur,whereas the neutralizing an-tibodies in the immunized sows in the five PEDV-uninfected farms were generally low,and their S1 IgG antibodies were also low,and only 8.1％(13/161)having S/P values higher than 3.5.The re-sults suggest that most sows in PEDV-infected farms can provide good immunoprotection to pig-lets after immunization,while pigs in PEDV-uninfected farms need further immunization if they need to achieve a higher level of immunoprotection.The present study provides a substantial clini-cal basis for the use of PEDV S1 IgG antibody levels to assess the effectiveness of PEDV antibody protection in swine herds.
