Innate immune recognition of protozoon parasites by Toll-like receptor 9
10.16303/j.cnki.1005-4545.2024.06.30
- VernacularTitle:Toll样受体9对原虫的天然免疫识别
- Author:
Liying YU
1
;
Naiwen ZHANG
;
Ruiming FAN
;
Yiwei ZHANG
;
Ning JIANG
Author Information
1. 沈阳农业大学动物科学与医学学院辽宁省人兽共患病研究重点实验室/辽宁省人兽共患病研究工程实验室,辽宁沈阳 110866
- Keywords:
Toll-like receptor 9;
protozoon parasite infection;
CpG DNA;
hemozoin
- From:
Chinese Journal of Veterinary Science
2024;44(6):1336-1341
- CountryChina
- Language:Chinese
-
Abstract:
The recognition of the innate immune system is the first line of defense for host protec-tion against invading microbes.Toll-like receptors(TLRs)are well-characterized pattern recogni-tion receptors that are critical for recognizing pathogen-associated molecular pattern(PAMP)and regulating the activation of antigen-presenting cells and key cytokines.Recognition of protozoon parasite genomic DNA by TLR9 activates transcription factors such as NF-κB,IRF3/7,and MAPK,which then induce the production of pro-inflammatory cytokines and type Ⅰ interferons.During parasite infection,MyD88 serves as a critical adapter protein for TLR9 to recognize PAMPs.Here,we review the TLR9-MyD88 pathways and their importance in the inflammatory re-sponse in some common protozoan parasite infections.We also discuss the impact of the subcellular localization of TLR9 in parasitic infectious diseases.By emphasizing current developments in these fields,the review aims to lay the foundation for future research on both the complexity of host-par-asite interactions and the prevention of protozoan parasitic diseases.
